Managing Depression - Duloxetine

Duloxetine is a prescription drug in the Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) family. Primarily, it is prescribed to relieve symptoms of depression, and it’s also effective as an anti-anxiety medication. Also effective in blocking nerve pain, it is effective in treating pain from these conditions:

· Fibromyalgia (chronic pain disorder)

· Chronic muscle pain (lower back pain for example)

· Chronic joint pain (osteoarthritis)

· Diabetic neuropathy (nerve damage resulting from diabetes


This drug class works by changing the levels of chemicals that naturally occur in the human body. Serotonin and norepinephrine are both neurotransmitters. SNRIs such as Duloxetine block the absorption, or reuptake in clinical terms, of these chemicals. Blocking this absorption increases the activity of these, and other, neurotransmitters.

When the balance of these substances chance, there is an effect that helps brain cells communicate. This effect improves the mood of the taker, in cases of depression and anxiety, and reduces nerve pain for the other conditions.

All SNRIs work in a similar fashion, but because of the chemical differences between them, side effects may vary, so these effects will vary from person-to-person.


Available in both regular and delayed-release capsules, Duloxetine is usually prescribed between 20 and 120 milligrams. Typically, treatment of depression starts with 20 mg prescribed twice a day. Anxiety and pain treatment usually starts higher, at 60 mg. Daily dosage rarely tops 120 mg, so check with your doctor for reasons if your dose is greater than this amount.

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Missed doses should be taken as soon as possible, unless the next dose is due soon. Don’t double your dose in this case, but resume your normal schedule after.

Duloxetine is thought to be safe for children in lower doses, but extensive research is not yet available. Avoid use during pregnancy and nursing.

Store Duloxetine as you would most drugs, at room temperature and away from heat and light sources and moisture, typical medicine cabinet conditions. Don’t let the drug freeze.


Duloxetine has a long list of chemicals with which it may interact, however in some cases benefits may outweigh potential conflicts. Let your doctor know all medications, prescription or over-the-counter, that you use either daily or incidentally, so that he can determine if Duloxetine is suitable for you.

Medical conditions that may negatively affect the use of Duloxetine include:

· Alcoholism

· Liver or kidney disease

· Diabetes

· Glaucoma

· High blood pressure

· Heart disease

Side Effects

Duloxetine has a few common side effects as well as many more that may occur in rare cases. Most common, occurring in more than 10 percent of patients, include constipation, dry mouth, nausea, headaches, dizziness, insomnia, weight changes and fatigue.

Any sign of an allergic reaction such as skin rash, difficulty breathing or swelling of the face, lips or tongue require emergency medical attention in case the reaction becomes severe.

Contact your doctor if any of these effects occur:

· Light-headedness, as though you’re fainting

· Vision problems such as blur, tunnel vision, eye pain

· Unusual bleeding or easy bruising

· Excessive tiredness

· Loss of appetite

· Irregular or racing heartbeat

Effects aren’t limited to these, so any change you notice should be discussed with your doctor

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What's more, duloxetine is utilized to help alleviate nerve torment (fringe neuropathy) in individuals with diabetes or progressing agony because of medicinal conditions, for example, joint inflammation, perpetual back ache etc.

It may enhance your temperament, slumber, hunger, and vitality level, and reduction anxiety. It can additionally lessening ache because of certain medicinal conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This pharmaceutical works by serving to restore the equalization of certain common substances in the mind.

Take this drug by mouth as controlled by your specialist, generally 1 or 2 times each day with or without sustenance. On the off chance that you have sickness, it may help to bring this medication with sustenance. Gulp down the container. Don't pulverize or bite the container or blend the substance with nourishment or fluid. Doing so can discharge the majority of the medication without a moment's delay, expanding the danger of symptoms.

The dose is focused around your restorative condition and reaction to treatment. To decrease your danger of reactions, your specialist may steer you to begin this prescription at a low measurements and slowly build your measurement. Take after your specialist's directions deliberately. Take this pharmaceutical customarily to get the most profit from it. To help you recollect, take it at the same time(s) every day.

It is paramount to keep taking this pharmaceutical as recommended regardless of the possibility that you feel well. Don't quit taking this prescription without counseling your specialist. A few conditions may get to be more regrettable when this medication is all of a sudden ceased. Additionally, you may encounter indications, for example, discombobulation, disarray, emotional episodes, migraine, tiredness, looseness of the bowels, slumber changes, and concise emotions like electric stun. Your dosage may need to be step by step diminished to diminish reactions. Report any new or exacerbating side effects quickly.

Tell your specialist if your condition holds on or exacerbates.

Precautionary measures:

- Before taking duloxetine, tell your specialist or drug specialist on the off chance that you are oversensitive to it; or on the off chance that you have another unfavorable susceptibilities. This item may contain inert fixings, which can result in hypersensitive responses or different issues. Converse with your drug specialist for more points of interest.

- Before utilizing this prescription, tell your specialist or drug specialist your therapeutic history, particularly of: individual or family history of psychiatric issue (such asbipolar/manic-depressive issue), individual or family history of suicide endeavors, draining issues, glaucoma, kidney ailment, liver infection, seizure issue, stomach issues, (for example, moderate discharging of the stomach), use/ill-use of liquor.

- This medication may make you unsteady or languid. Don't drive, use hardware, or do any movement that obliges readiness until you are certain you can perform such exercises securely. Keep away from jazzed up drinks.

- On the off chance that you have diabetes, duloxetine may influence your glucose levels. Check your glucose levels normally as administered by your specialist. Your specialist may need to modify your diabetes pharmaceutical, activity program, or eating regimen.

-Before having surgery, inform your specialist or dental practitioner concerning all the items you utilize (counting professionally prescribed medications, nonprescription medications, and home grown.

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